Status:
COMPLETED
Prospective Phase 2 Trial of Cabazitaxel in Patients With Temozolomide Refractory Glioblastoma Multiforme
Lead Sponsor:
University of Ulm
Conditions:
Glioblastoma Multiforme (GBM) WHO Grade IV
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The proposed study is an open-label, single-arm, Phase- II trial to assess the efficacy of cabazitaxel in GBM WHO grade IV patients with a progression during or within 6 months after last temozolomide...
Eligibility Criteria
Inclusion
- Both female and male patients meeting the mentioned inclusion and exclusion criteria will be included in this clinical trial. Patients must meet ALL of the following inclusion criteria to be eligible for enrollment into the study:
- Patients with diagnosis glioblastoma multiforme (GBM) WHO grade IV (histologically confirmed by a pathologist)
- Progression during or within 6 months after last temozolomide treatment
- Time since last temozolomide \> 21 days
- Prior external beam radiotherapy (54 to 62 Gy), no option for subsequent radiotherapy
- No clinical and radiological signs of intracerebral inflammation (in pre-study MRI not older than 4 weeks)
- Patients \> 18 years of age.
- ECOG performance status of ≤ 2 (stable over 4 weeks prior to study entrance)
- Female patients of childbearing potential with a negative pregnancy test within 7 days of initiation of study treatment. Postmenopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential.
- Male and female patients of reproductive potential who agree to employ an effective method of birth control throughout the study and for up to 6 months following discontinuation of study drug.
- Signed informed consent prior to initiation of any study procedure (Must understand, voluntarily sign the informed consent form and be able to adhere to the study visit schedule and other protocol requirements.)
Exclusion
- The presence of ANY of the following criteria will exclude a patient from study enrollment:
- Female patients who are pregnant or breast-feeding
- History of severe hypersensitivity reaction (≥grade 3) to any component of the investigational drugs or excipients (allergy to or other intolerability of gadolinium, docetaxel, cabazitaxel or polysorbate 80 containing drugs)
- Unable to undergo Gd-MRI
- Time since external beam radiotherapy \<12 weeks
- Patients who have been treated with any investigational agent(s) within 28 days of the first day of administration of study drug.
- Current active second malignancy other than non-melanoma skin cancers and post-treatment of localized prostate cancer. Patients are not considered to have a currently active malignancy if they are in complete remission for \> 3 years prior to study
- Uncontrolled severe illness or medical condition (including uncontrolled diabetes mellitus)
- Known HIV infection, active Hepatitis B or C infection
- Any serious and/or unstable pre-existing psychiatric or other condition that could interfere with subject's safety, provision of informed consent, or compliance to study procedures
- Any ongoing toxicity from prior anti-cancer therapy that is \> grade 1 and/or that is progressing in severity (except alopecia) and delayed hematological recovery following last temozolomide cycle
- Additional anti-cancer treatment for GBM other than study drug and supportive measures (i.e. dexamethasone)
- Inadequate organ and bone marrow function as evidenced by:
- Hemoglobin \<9.0 g/dL
- Absolute neutrophil count \<1.5 x 109/L,
- Platelet count \<100 x 109/L,
- AST/SGOT and/or ALT/SGPT \>1.5 x ULN;
- Total bilirubin \>1.0 x ULN,
- Serum creatinine \>1.5 x ULN. If creatinine 1.0 - 1.5 x ULN, creatinine clearance will be calculated according to CKD-EPI formula and patients with creatinine clearance \<60 mL/min should be excluded
Key Trial Info
Start Date :
October 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 25 2017
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT01866449
Start Date
October 1 2013
End Date
August 25 2017
Last Update
October 26 2017
Active Locations (3)
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1
Hämatologisch onkologische Praxis
Augsburg, Germany, 86150
2
Stiftungsklinikum Mittelrhein GmbH
Koblenz, Germany, 56068
3
Lars Bullinger, MD
Ulm, Germany, 89081