Status:
COMPLETED
Early Retinal Nerve Fiber Layer Change of Ethambutol Optic Neuropathy by Optical Coherence Tomography
Lead Sponsor:
Yonsei University
Conditions:
Primary Lung Tuberculosis
Eligibility:
All Genders
20-70 years
Brief Summary
Ethambutol is widely used as first-line drug, but has serious side effect of optic neuropathy. As previously reported, incidence of ethambutol optic neuropathy is about 1\~2%, there was considerable s...
Eligibility Criteria
Inclusion
- Primary lung tuberculosis who has not previously treated
- Age more than 19 years and less than 70 years old
Exclusion
- spherical equivalent more than +6.00 diopter or less than -6.00 diopter by autorefraction
- Closed angel or intraocular pressure more than 21 mmHg
- Best corrected visual acuity less than 0.5 with severe cataract
- Retinal disorder include branch retinal vein occlusion, diabetic macular edema, wet-type age-related macular degeneration
- Age less than 20 years or older than 70 years old
- Any intraocular surgery less than 3 months
- Intellectual problems or illiterate whom could not obtained informed consent
Key Trial Info
Start Date :
May 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2014
Estimated Enrollment :
49 Patients enrolled
Trial Details
Trial ID
NCT01866579
Start Date
May 1 2013
End Date
May 1 2014
Last Update
May 20 2014
Active Locations (1)
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1
Department of Ophthalmology, Gangnam Severance Hospital
Seoul, Seoul, South Korea, 146-92