Status:
COMPLETED
The Effect of Aspirin Desensitization on Patients With Aspirin-exacerbated Respiratory Diseases
Lead Sponsor:
Tehran University of Medical Sciences
Collaborating Sponsors:
Rassoul Akram Hospital
Conditions:
Asthma, Aspirin-Induced
Eligibility:
All Genders
18-90 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine the effect of aspirin desensitization on symptoms and immunologic profile of patients with aspirin-exacerbated respiratory diseases (AERD).
Eligibility Criteria
Inclusion
- Patients with clinical diagnose of aspirin-exacerbated respiratory disease
- History of physician diagnosed asthma.
- History of physiacian diagnosed chronic rhinosinositis with nasal polyps.
- Positive reaction to aspirin challenge test.
- Stable asthma (post-bronchodilator FEV1 of 70% or better, no increase in baseline dose of oral glucocorticoids for at least 3 months, and no history of hospitalization or emergency room visits for asthma for at least the prior 6 months).
Exclusion
- Being smoker
- pregnancy
- Current breastfeeding
- History of bleeding diathesis
- History of transient ischemic attack or stroke, or diabetes.
- History of abnormal hepatic function
- Uncontrolled hypertension or use of beta blocker medication.
- History of gastrointestinal ulcers or gastrointestinal bleeding.
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT01867281
Start Date
June 1 2013
End Date
June 1 2014
Last Update
July 1 2014
Active Locations (1)
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1
Department of Allergy and Immunology, Rasool-e-Akram Hospital, Tehran University of Medical Sciences
Tehran, Tehran Province, Iran