Status:
TERMINATED
Effects of Atypical Antipsychotics on Brain Function in Children and Teens With Conduct Disorders
Lead Sponsor:
National Institute of Mental Health (NIMH)
Collaborating Sponsors:
Boys Town Research Hospital
Conditions:
Conduct Disorder
fMRI
Eligibility:
All Genders
10-18 years
Brief Summary
Background: \- Some children and teenagers have conditions known as conduct disorders. They often have long-term chronic behavior problems, such as defiant behavior or violence. Conduct disorders are...
Detailed Description
Objective: To determine the impact, as indexed by BOLD response, of the administration of aripiprazole and risperidone during the treatment of Conduct Disorder (CD) on the pathophysiology of CD. Stud...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Youth with Conduct Disorder (CD)
- 10-18 years of age.
- A current diagnosis of CD.
- Currently taking aripiprazole, risperidone or unmedicated with antipsychotics.
- Typically developing (TD) youth
- 10-18 years of age.
- No current psychiatric diagnosis.
- EXCLUSION CRITERIA:
- I.Q.\< 80.
- Pregnancy.
- Ongoing medical illness requiring the following medications:
- Beta blockers
- Steroids
- Receipt of any antipsychotic medication other than aripiprazole or risperidone.
- Receipt of risperidone for the CD group medicated with aripiprazole.
- Receipt of aripiprazole for the CD group medicated with risperidone.
- Receipt of antipsychotics for the un-medicated CD group.
- Explicit exclusions include active psychosis, Pervasive Developmental
- Neurologic disorder (including seizures).
- Any ferromagnetic metallic objects in the body. Metal plates, certain types of dental braces, cardiac pacemakers, etc., that are sensitive to electromagnetic fields contraindicate MRI scans.
- Claustrophobia
Exclusion
Key Trial Info
Start Date :
April 29 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 18 2015
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01867398
Start Date
April 29 2013
End Date
May 18 2015
Last Update
December 12 2019
Active Locations (1)
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1
Boys Town Research Hospital
Omaha, Nebraska, United States