Status:
COMPLETED
MET-PET for Newly Diagnosed Glioblastoma
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Glioblastoma
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
This research study is a prospective pilot study. The purpose of a pilot clinical study is to obtain preliminary data to support the reason for doing a larger clinical trial on testing the clinical ef...
Detailed Description
After agreeing to take part in this research study you will be asked to undergo some screening tests or procedures to confirm that you are eligible. Many of these tests and procedures are likely to be...
Eligibility Criteria
Inclusion
- Histologically or cytologically confirmed newly-diagnosed glioblastoma or gliosarcoma and planning to undergo standard chemoradiation treatment
- Life expectancy of at least 12 weeks
Exclusion
- Pregnant or breastfeeding
- Glioblastoma involving the brainstem or posterior fossa, cerebrospinal fluid dissemination
- Chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas)
- Not recovered from adverse events due to previous treatment
- Have received any treatment regimen including a VEGF-R inhibitor such as bevacizumab or cediranib or plant to receive such agents
- Prior history of radiation therapy that would lead to overlap wtih new radiation fields
- Prior use of radiosensitizers, Gliadel wafers or other interstitial intracranial treatments
- Receiving any other study agent
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to L-\[methyl\]-C methionine
- Prior invasive malignancy (except non-melanomatous skin cancer or disease free for at least 3 years)
- Inability to undergo MRI with gadolinium contrast or PET imaging
- Uncontrolled intercurrent illness
- HIV positive on antiretroviral therapy
Key Trial Info
Start Date :
January 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2016
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01867593
Start Date
January 1 2014
End Date
September 1 2016
Last Update
October 13 2017
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114