Status:
COMPLETED
Epithelial Damage in GERD
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Gastro-esophageal Reflux Disease
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to characterize and compare epithelial damage in patients with erosive esophagitis and non-erosive reflux disease.
Eligibility Criteria
Inclusion
- Typical GERD-symptoms lasting for more than 6 months (recurrent episodes of heartburn or acid regurgitation)
- abnormal pH-parameters (pathological acid exposure and/or symptom association)
Exclusion
- Age \<18 years
- Previous esophageal or gastric surgery
- Severe esophageal motility disorder on manometry
- Histological evidence of Barrett's mucosa
- Severe co-morbidities (including cardiopulmonary disease, portal hypertension, collagen diseases, morbid obesity, coagulation disorders and co-morbidity hindering a gastroscopic procedure)
- Use of anticoagulant or immunosuppressive drugs
- Inability to stop medication that can influence the test results, like PPI, for at least 10 days before tests
- Excessive alcohol consumption (\>20 units per week)
- Patients unable to give informed consent.
Key Trial Info
Start Date :
April 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2014
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT01867931
Start Date
April 1 2013
End Date
October 1 2014
Last Update
February 20 2015
Active Locations (1)
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1
Maastricht University Medical Center
Maastricht, Netherlands, 6229 HX