Status:
UNKNOWN
Pharmacogenetic and Neurofunctional Brain Areas Study in Obese Patients With Binge Eating Disorder
Lead Sponsor:
Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Conditions:
Obesity
Binge Eating Disorder
Eligibility:
All Genders
18-50 years
Brief Summary
Adoption, twin and family studies have reported that obesity has a strong heritable component and in particular, it has been suggested that BMI in adults is due to genetic influence rather than shared...
Detailed Description
Obesity has been declared the number one illness of the 21st Century in industrialized countries, and is reaching epidemic proportions. Adoption, twin and family studies have reported that obesity has...
Eligibility Criteria
Inclusion
- Patients of Eating Disorders Clinic with a diagnosis of Bulimia Nervosa, Eating Disorders Not Otherwise Specified 3 and 6 with Binge Eating Disorder according to research criteria in Diagnostic and Statistical of Mental Disorders, version IV revised, who started taking Topiramate.
- Probands with diagnosis of obesity (BMI ≥30 kg/m2- 40 kg/m2).
- Capable to give written informed consent.
- Age of 18 to 50 years at screening.
- Maternal and paternal grandparents of Mexican descent.
- Probands without psychopharmacological treatment (including anticonvulsants) at least 4 weeks before inclusion.
Exclusion
- Subjects with alcohol or substance abuse or dependence.
- Any psychiatric or medical disorder that requires inpatient treatment.
- Psychosis or suicidal thoughts.
- Abnormal blood chemistry.
- Diabetes uncontrolled.
- Unstable hypertension or difficult to control (criterion 7 of inclusion section).
- Metabolic acidosis.
- Narrow-angle glaucoma.
- Unstable hypothyroidism or hyperthyroidism.
- Unable or unwilling to give a blood sample.
- Pace-makers or metal implants that would preclude the functional Magnetic Resonance Image scan.
- Pregnant or lactating women at screening or positive blood pregnancy test.
- Presence of any epileptic disorder.
- Subjects unable or unlikely to follow the protocol procedures.
Key Trial Info
Start Date :
June 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2014
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01868204
Start Date
June 1 2013
End Date
March 1 2014
Last Update
June 4 2013
Active Locations (1)
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1
Instituto Nacional de Psiquiatria Ramon de la Fuente Muñiz
México, D.f., Mexico, 14370