Status:
COMPLETED
Tranexamic Acid During Cystectomy Trial (TACT)
Lead Sponsor:
Ottawa Hospital Research Institute
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Dalhousie University
Conditions:
Bladder Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
A cystectomy is the removal of the bladder and adjacent organs in patients with bladder cancer. This often results in significant blood loss, and about 60% of patients will require a blood transfusion...
Detailed Description
Removal of the bladder and adjacent organs in patients with bladder cancer (radical cystectomy) often results in significant blood loss, and approximately 60% of patients require peri-operative blood ...
Eligibility Criteria
Inclusion
- Participant ≥ 18 years at time of consent
- Participant has bladder cancer and will undergo radical cystectomy to remove bladder
- Participant is willing to receive blood products (i.e. packed red blood cells, platelets, plasma)
- Have obtained Informed Consent
Exclusion
- Participant declines consent
- Participants incapable (incompetent) of providing Informed Consent
- Participant is under 18 years
- Participant is unwilling to receive blood products due to personal reasons
- Participant has thromboembolic disease (active or diagnosed within 1 year) such as deep vein thrombosis, pulmonary embolism or cerebral thrombosis)
- Participant with known personal history of subarachnoid haemorrhage.
- Participant has acquired disturbances to his / her colour vision (does not apply to congenital colour blindness)
- Participant is pregnant (confirmed by βHCG test)
- Participant has a known allergy to tranexamic acid
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2021
Estimated Enrollment :
354 Patients enrolled
Trial Details
Trial ID
NCT01869413
Start Date
June 1 2013
End Date
June 1 2021
Last Update
October 4 2022
Active Locations (10)
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1
Northern Alberta Urology Centre
Edmonton, Alberta, Canada, T6G 1Z1
2
St. Boniface General Hospital
Winnipeg, Manitoba, Canada, R2H 2A6
3
Queen Elizabeth II Health Sciences Centre
Halifax, Nova Scotia, Canada, B3H 2Y9
4
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada, L8N 4A6