Status:
COMPLETED
Effect of Minocycline on Pain Caused by Nerve Damage
Lead Sponsor:
Ziekenhuis Oost-Limburg
Conditions:
Neuropathic Pain Caused by Lumbar Radicular Pain
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine if minocycline is effective in the treatment of neuropathic pain. The effect of minocycline will be compared to the effect of placebo and amitriptyline.
Detailed Description
Neuropathic pain is pain caused by damage to the central or peripheral nervous system. To date, therapy consists of tricyclic antidepressants (such as amitriptyline) or anticonvulsants. However, resul...
Eligibility Criteria
Inclusion
- Lumbar radicular pain due to disc herniation, failed back surgery syndrome or spinal canal stenosis causing neuropathic pain
Exclusion
- Diabetic, alcoholic or drug induced polyneuropathies
- Depression or psychiatric comorbidity affecting pain sensation.
- Use of antidepressants
- Fibromyalgia and Chronic Fatigue Syndrome
- Pregnancy.
- Previous spinal cord damage
- Malignancies
- Allergy to minocycline or amitriptyline
Key Trial Info
Start Date :
September 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2014
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01869907
Start Date
September 1 2011
End Date
August 1 2014
Last Update
January 27 2015
Active Locations (1)
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1
Ziekenhuis Oost-Limburg
Genk, Limburg, Belgium, 3600