Status:
WITHDRAWN
Differential Effects of Various Anesthetic Agents on Cognitive Function in Patients With Alzheimer's Disease
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
Alzheimer's Association
Conditions:
Alzheimer Disease
Eligibility:
All Genders
Brief Summary
The objective of the study is to determine the effects of different anesthetic agents on cognitive function in patients with Alzheimer's disease (AD). The investigators will test the hypothesis that a...
Detailed Description
Patients with mild-to-moderate Alzheimer's disease who are scheduled to have elective noncardiac, nonneurologic, nonvascular surgery will be recruited at the Massachusetts General Hospital (MGH). The ...
Eligibility Criteria
Inclusion
- Patients diagnosed with Alzheimer's disease (AD) per Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria.
- Patient recruitment permission granted by his/her surgeon
- Requires general anesthesia for elective noncardiac, nonneurologic, nonvascular surgery.
Exclusion
- History of neurologic or psychiatric disease (i.e. stroke, psychosis, etc.)
- Non-native English speaker
- Severe visual or auditory disorder
- Sensitivity to sulfites (some propofol formulations at MGH may contain sodium metasulfite).
- Asthma (sulfite sensitivity is seen more frequently in asthmatic than in non-asthmatic people).
Key Trial Info
Start Date :
October 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2018
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01870453
Start Date
October 1 2013
End Date
December 1 2018
Last Update
August 16 2018
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114