Status:
RECRUITING
Ovarian Tissue Transplantation
Lead Sponsor:
Abramson Cancer Center at Penn Medicine
Conditions:
Infertile Females or Females With Ovarian Insufficiency
Eligibility:
FEMALE
18-45 years
Phase:
NA
Brief Summary
Chemotherapy and radiation therapy for the treatment of cancer can compromise fertility. Ovarian tissue cryopreservation is an experimental strategy offered at The University of Pennsylvania to preser...
Eligibility Criteria
Inclusion
- Female patient between the ages of 18 and 45 years
- Previously cryopreserved and stored cortical ovarian tissue available for autologous transplantation
- Ovarian insufficiency defined as an elevated FSH over 10
- Inability to conceive after 6 months of unprotected intercourse with male
- Reasonably good health
- Candidate for pregnancy
- Written clearance for the procedure from the patients oncologist
Exclusion
- Patients considered to be high risk for surgical complications will be excluded from the research protocol
- Women who are known to be positive for the BRCA mutation
- Women with a history of leukemia, ovarian cancer or a cancer that likely involved the ovaries at the time of ovarian tissue collection
- Women with psychological, psychiatric, or other conditions which prevent giving fully informed consent
- Current pregnancy
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT01870752
Start Date
June 1 2013
End Date
December 1 2028
Last Update
September 10 2025
Active Locations (1)
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1
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104