Status:
COMPLETED
Effect of Exercise Training on Protein Expression in Skeletal Muscle Tissue After Exercise in Peripheral Arterial Disease
Lead Sponsor:
Flinders University
Collaborating Sponsors:
Flinders Medical Centre
Royal Adelaide Hospital
Conditions:
Peripheral Arterial Disease
Eligibility:
All Genders
Phase:
NA
Brief Summary
Cardiovascular disease remain one of the leading causes of death in Australia, accounting for 47637 (36%) of deaths in 2004. Peripheral arterial disease (PAD) is a category of cardiovascular disease,...
Detailed Description
Why is this clinical problem important? Peripheral Arterial Disease (PAD) is a major health problem in Australia, with a prevalence of 15% in males aged over 65 years. The direct health care cost of ...
Eligibility Criteria
Inclusion
- All claudicants with a walking distance of 50 metres or more with a resting ankle brachial index equal to or less than 0.9.
- Claudicants meeting above criteria, who may have previously had a percutaneous arterial intervention for symptom control more than 12 months ago.
Exclusion
- Patients with lower limb pain of other aetiologies - neurogenic claudication evidenced by normal ankle brachial indices and duplex ultrasound.
- Patients with lower limb ischaemic rest pain
- Patients with current or previous tissue loss, such as ulcers or necrotic lesions.
- Patients with recent (\<12 months) history of peripheral vascular interventions for symptoms.
- Patients with pre-existing cardiac or respiratory problems limiting exercise.
- Patients with previous disabling strokes which would restrict exercise regimes
- Patients with anticoagulation or blood dyscrasias.
- Women who are pre-menopausal,
- Women receiving hormone-replacement therapy.
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2013
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT01871779
Start Date
October 1 2010
End Date
February 1 2013
Last Update
June 7 2013
Active Locations (1)
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1
Repatriation General Hospital
Daw Park, South Australia, Australia, 5041