Status:
UNKNOWN
HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Conditions:
Acute Lymphoblastic Leukemia
Eligibility:
All Genders
16-65 years
Phase:
PHASE4
Brief Summary
Intensified conditioning regimen allo-HSCT is based on a hypothesis of that intensifying condition with less-used drugs could overcome resistance,reduce tumor burden, and most importantly, spare enoug...
Detailed Description
It's well-known that the long-term outcome of adult acute lymphoblastic leukemia (ALL) lags far behind that of pediatric ALL,associated with different molecular cytogenetics make-up and treatment stra...
Eligibility Criteria
Inclusion
- Age: 16 years to 65 years;
- Diagnosis of acute lymphoblastic leukemia;
- Patient receives allo-HSCT;
- The informed consent form has been signed;
Exclusion
- Patient with severe cardiac dysfunction with less than 50% EF;
- Patient with severe lung dysfunction;
- Patient with more than 3 times ULN of serum ALT or AST levels, or with more than 2 times ULN of serum TBIL level, or less than 40% of normal prothrombin time activity (PTA); or with more than 2 times the ULN of serum Cr;
- Patient with severe active infection;
- Patient with allergy history about suspected drug in conditioning regimen;
- Patient with other conditions considered unsuitable for the study.
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2015
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01873807
Start Date
May 1 2013
End Date
December 1 2015
Last Update
October 9 2015
Active Locations (13)
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1
Department of Hematology, Union Hospital of Fujian Medical University
Fuzhou, Fujian, China
2
Guangzhou General Hospital of Guangzhou Military Command
Guangzhou, Guangdong, China, 510010
3
Guangdong General Hospital
Guangzhou, Guangdong, China, 510030
4
Guangdong No.2 Provincial People's Hospital
Guangzhou, Guangdong, China, 510317