Status:
COMPLETED
Circulating miR-126 as a Novel Biomarker for Post Myocardial Infarction Remodeling
Lead Sponsor:
Qilu Hospital of Shandong University
Collaborating Sponsors:
Qianfoshan Hospital
Jinan Central Hospital
Conditions:
Myocardial Infarction
Left Ventricular Remodeling
Eligibility:
All Genders
18+ years
Brief Summary
Purpose: The purpose of this study is to evaluate the impact of circulating miR-126 on left ventricular remodeling and clinical outcomes in patients undergoing primary percutaneous coronary interventi...
Eligibility Criteria
Inclusion
- Admitted for primary PCI for STEMI involving the LAD within 12 hours of onset of symptoms. STEMI will be defined as typical ECG changes (ST segment elevation ≥2mm in 2 or more precordial leads) associated with acute chest pain or an elevation of cardiac enzymes;
- Age ≥18 years;
- Informed consent from patient or next of kin.
Exclusion
- Nonischaemic Cardiomyopathy;
- Cardiac surgery planed in the 6 months;
- Mechanical complication of STEMI (ventricular septal rupture, free wall rupture, acute severe mitral regurgitation);
- Renal or hepatic failure;
- Malignancy, HIV, or central nervous system disorder;
- Cardiopulmonary resuscitation \>15 min and compromised level of consciousness;
- Cardiogenic shock;
- Current participation in any research study involving investigational drugs or devices;
- No written consensus;
- Previous myocardial infarction.
Key Trial Info
Start Date :
February 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2015
Estimated Enrollment :
1200 Patients enrolled
Trial Details
Trial ID
NCT01875484
Start Date
February 1 2012
End Date
July 1 2015
Last Update
July 30 2015
Active Locations (17)
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1
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
2
Affiliated Hospital of Binzhou Medical Universty
Binzhou, Shandong, China
3
Heze Municipal Hospital
Heze, Shandong, China
4
Qianfoshan Hospital, Shandong University
Jinan, Shandong, China, 250012