Status:
COMPLETED
PK of Serelaxin in Severe Renal Impairment and ESRD
Lead Sponsor:
Novartis Pharmaceuticals
Conditions:
Renal Failure, Chronic
End-Stage Renal Disease
Eligibility:
All Genders
18-75 years
Phase:
PHASE1
Brief Summary
The study is designed to evaluate the pharmacokinetics, safety and tolerability, immunogenicity and pharmacogenetics of a single dose of serelaxin/RLX030 in patients with severe renal impairment and e...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- All subjects
- \- at least 50 years; body mass index (BMI) within the range of 18 - 35 kg/m2.
- Patients with severe renal impairment / ESRD
- Severe renal impairment (clinically significantly abnormal creatinine and creatinine clearance (15mL/min/1.73m2≤eGFR\<30mL/min/1.73m2) or ESRD on hemodialysis.
- Sitting vital signs should be within the following ranges:
- oral body temperature between 35.0-37.5 °C
- systolic blood pressure, 110 to 170 mm Hg
- diastolic blood pressure, 60 to 105 mm Hg
- pulse rate, 45 - 100 bpm
- Healthy subjects
- eGFR \> 90mL/min/1.73m2;
- matching in race, age (±10 years), gender, BMI (±15%) to a subject with renal impairment
- Subject must be in good health.
- Sitting vital signs should be within the following ranges:
- oral body temperature between 35.0-37.5 °C
- systolic blood pressure, 100 to 150 mm Hg
- diastolic blood pressure, 60 to 95 mm Hg
- pulse rate, 50 to 100 bpm
- Exclusion Criteria:
- All subjects
- History of clinically significant ECG abnormalities at Screening or Baseline.
- Pregnant or nursing (lactating) women
- Women of child-bearing potential unless they are using highly effective methods of contraception during dosing of study treatment.
- Sexually active males (incl. vasectomized men) must use a condom during intercourse while taking drug and for 2 weeks after stopping study medication.
- Recent (within the last three years) and/or recurrent history of autonomic dysfunction (e.g., recurrent episodes of fainting, palpitations, etc.).
- Patients with severe renal impairment / ESRD:
- Presence of any non-controlled and clinically significant disease, surgical or medical condition that could affect the study outcome or that would place the patient at undue risk as judged by the investigator.
- Hemoglobin levels below 9.0 g/dL at screening and baseline, other laboratory parameters at screening and baseline outside acceptable limits .
- Treatment with any cytostatic drug or autonomic alpha blocker.
- Healthy subjects:
- Use of any prescription drugs (other than hormonal contraception, herbal supplements, within four (4) weeks prior to initial dosing, and/or over-the-counter (OTC) medication, dietary supplements (vitamins included) within two (2) weeks prior to initial dosing.
- History or presence of any disease, surgical or medical condition of any major system organ class considered clinically significant by the investigator.
- Laboratory parameter at screening and baseline outside of normal limits. For small deviations which could be attributed to the characteristics of the subjects (e.g. age) it will be to the discretion of the investigator to consider them as exclusive or not.
- A positive Hepatitis B surface antigen or Hepatitis C test result.
Exclusion
Key Trial Info
Start Date :
August 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT01875523
Start Date
August 1 2013
End Date
December 1 2013
Last Update
December 21 2020
Active Locations (1)
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1
Novartis Investigative Site
Grünstadt, Germany, D-67269