Status:
COMPLETED
Autoantibodies to Gastric Parietal Cells in Rheumatoid Arthritis Patients
Lead Sponsor:
Keesler Air Force Base Medical Center
Conditions:
Vitamin B12 Deficiency
Eligibility:
All Genders
18+ years
Brief Summary
A review of the literature reveals that very few studies have assessed the potential co-existence of vitamin B12 deficiency due to gastric parietal cell autoantibodies. While Segal et al. in 2004 publ...
Detailed Description
Background: Organ specific antibodies such as anti-gastric parietal cell antibodies (anti-GPC Ab) have been found in a variable number of patients with RA, but it is unclear what significance these an...
Eligibility Criteria
Inclusion
- Adult, age 18 and older
- RA arm: History of Rheumatoid Arthritis
- AITD arm: History of an autoimmune thyroid disease without a history or clinically obvious manifestation of an organ specific or systemic autoimmune process.
- Control arm: No history of RA and no history or clinically obvious manifestation of an organ specific or systemic autoimmune process.
Exclusion
- Known vitamin B12 deficiency for which the participant was formerly treated or continues to receive therapy.
- Active malabsorptive state to include but not limited to celiac disease, inflammatory bowel disease, etc.
- Surgically induced malabsorptive state to include but not limited to Roux-en-Y Gastric bypass
- Use of medications that may interfere with vitamin B12 absorption
- Patients with a thyroid condition not consistent with an autoantibody process (i.e. congenital absence of the thyroid, infectious thyroiditis, thyroidectomy for non-autoimmune process, toxic multinodular goiter) will be excluded from the autoimmune thyroid arm.
Key Trial Info
Start Date :
June 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2015
Estimated Enrollment :
125 Patients enrolled
Trial Details
Trial ID
NCT01876329
Start Date
June 1 2013
End Date
April 1 2015
Last Update
May 29 2015
Active Locations (1)
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1
Keesler Medical Center
Keesler Air Force Base, Mississippi, United States, 39534