Status:
COMPLETED
Study of MK-3475 in Patients With Microsatellite Unstable (MSI) Tumors (Cohorts A, B and C)
Lead Sponsor:
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Conditions:
MSI Positive Colorectal Cancer
MSI Negative Colorectal Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This study will be looking at whether MK-3475 (an antibody that blocks negative signals to T cells) is effective (anti-tumor activity) and safe in three different patient populations. These include: 1...
Eligibility Criteria
Inclusion
- Cohort A only: Patients with microsatellite instability (MSI) positive colorectal cancer
- Cohort B only: Patients with MSI negative colorectal cancer
- Cohort C only: Patients with MSI positive non-colorectal cancer -
- Have measurable disease
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1
- Adequate organ function as defined by study-specified laboratory tests
- Must use acceptable form of birth control through the study and for 28 days after final dose of study drug
- Signed informed consent form
- Willing and able to comply with study procedures
- Agree to have a biopsy of participants' cancer
- Patients with colon cancer must have received at least two prior cancer therapy regimens.
- Patients with other cancer types must have received at least one prior cancer therapy
- Progressive disease
Exclusion
- Patients with uncontrolled intercurrent illness, including but not limited to ongoing or active infection, systematic congestive heart failure, unstable angina pectoris, cardiac arrhythmia or psychiatric condition that would limit compliance with study requirements.
- Patients who have had chemotherapy or biological cancer therapy within 2 weeks prior to the first dose of study drug
- Patients who have had radiation within 2 weeks prior to the first dose of study drug
- Patients who have undergone major surgery within 4 weeks of dosing of investigational agent
- Patients who have received another investigational product or investigational device within 4 weeks prior to receiving study drug
- Patients who have received any of the following concomitant therapy: Interleukin-2 (IL-2), interferon, or other non-study immunotherapy regimens, immunosuppressive agents, other investigational therapies or chronic use of systemic corticosteroids within one week prior to first dose of study drug
- Patients who have received a live vaccine within 4 weeks prior to or after any dose of MK-3475 (exception: inactivated flu vaccines)
- Patients who have received growth factors, including but not limited to granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage-colony stimulating factor (GM-CSF), erythropoietin, etc. within 2 weeks of study drug administration
- Patient who have had prior treatment with anti-PD-1 (anti-programmed cell death protein 1), anti-PD-L1, anti-PD-L2, anti-CD137, anti-OX-40, anti-CD40, or anti-CTLA-4 antibodies
- Patients with history of any autoimmune disease:inflammatory bowel disease, (including ulcerative colitis and Crohn's Disease), rheumatoid arthritis, systemic progressive sclerosis (scleroderma), systemic lupus erythematosus (SLE) autoimmune vasculitis, central nervous system (CNS) or motor neuropathy considered to be of autoimmune origin.
- Patients who have known history of infection with HIV, hepatitis B, or hepatitis C
- Patients with evidence of interstitial lung disease
- Systemically active steroid use
- Patients on home oxygen
- Patients with oxygen saturation of \<92% on room air by pulse oximetry
- Pregnant or lactating
- Conditions, including alcohol or drug dependence, or intercurrent illness that would affect the patient's ability to comply with study visits and procedures
- Patient with known active central nervous system metastases and/or carcinomatous meningitis.
- Patients with primary brain tumors.
- Requires any other form of systemic or localized antineoplastic therapy while on study
- Has any tissue or organ allograft
- Patients with history of allogeneic hematopoeitic stem cell transplant
Key Trial Info
Start Date :
September 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2019
Estimated Enrollment :
113 Patients enrolled
Trial Details
Trial ID
NCT01876511
Start Date
September 1 2013
End Date
August 1 2019
Last Update
February 6 2020
Active Locations (7)
Enter a location and click search to find clinical trials sorted by distance.
1
Stanford University
Stanford, California, United States, 94305
2
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, United States, 21231
3
Investigator Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, NIH
Bethesda, Maryland, United States, 20892
4
Ohio State University
Columbus, Ohio, United States, 43210