Status:
COMPLETED
Bioactive Glass (Sol-gel) for Alveolar Bone Regeneration After Surgical Extraction
Lead Sponsor:
Alexandria University
Collaborating Sponsors:
Lehigh University
Conditions:
Bone Loss
Vertical Alveolar Bone Loss
Eligibility:
All Genders
9-16 years
Phase:
NA
Brief Summary
The purpose of the present research is to evaluate the effect of bioactive glass in bone regeneration immediately following extraction of mandibular and maxillary premolars.The hypothesis of the study...
Detailed Description
Bioactive glass has long been known as a bone graft substitute capable of bone augmentation. The current proposal introduces a newly tailored bioactive glass scaffold with multi-scale porosity prepare...
Eligibility Criteria
Inclusion
- Patients must have good oral hygiene (confirmed by OHI-S)
- Patients who had voluntarily agreed on signing an informed consent including the duration and all the steps of the trial
- Patients who are indicated for the administration of the type of local anesthesia used in the trial
- Patients who need myofunctional therapy including premolar extraction as part of two stage treatment (class II division I)
- Patients indicated for premolar extraction as a normal step in the treatment plan not intentionally for the experiment.
- Patients who had undergone x- rays on the premolar teeth showing root form and the shape of the socket prior to extraction
Exclusion
- Patients with history of bleeding disorders which will hinder the normal healing process of the needed sockets for the trial
- Patients with history of allergy to foreign bodies , i.e. susceptible to reactions from Bioglass
- Patients with history of hypertension and diabetes , rendering them not indicated for administration of the recommended type of local anesthesia nor even for extraction
- Patients having HCV , HBV , HIV or other infectious diseases to make sure of the safety of the research team and the participants from probable infection .
- Mentally retarded patients who are not able to understand the steps of the trial Patients with systemic diseases or febrile illness making them unable to follow the appointments arranged
- Patients who simultaneously participate in other research studies
- Patients with traumatic surgical extraction
Key Trial Info
Start Date :
October 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2018
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT01878084
Start Date
October 1 2013
End Date
January 1 2018
Last Update
February 18 2020
Active Locations (1)
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1
Tissue Engineering Laboratories, Faculty of Dentistry, Alexandria University
Alexandria, Egypt