Status:
COMPLETED
Prospective Trial of Two Hypofractionated Radiotherapy Regimens Versus Conventional Radiotherapy in Diffuse Brainstem Glioma in Children
Lead Sponsor:
Children's Cancer Hospital Egypt 57357
Conditions:
Pediatric Brain Stem Glioma
Eligibility:
All Genders
2-18 years
Phase:
NA
Brief Summary
This Trial offers a reduction in patient burden, which is especially preferable in children with a poor compliance and poor performance status. This prospective randomized trial was extension to the p...
Detailed Description
In this study will add a third arm in which we will increase in the total dose to 4500 cGy in 15 fractions in 3 weeks may lead to improvement in Over-all survival or Progression-Free Survival.
Eligibility Criteria
Inclusion
- Newly diagnosed patients with a diffuse intrinsic brainstem glioma
- Aged 2-18years,
- Have symptoms for less than 3 months and at least two findings of the neurologic triad: cranial nerve deficits, ataxia, or long tract signs.
- No performance criteria were required for entry onto the study.
Exclusion
- Children were not eligible if they had received any prior therapy other than steroids Treatment
Key Trial Info
Start Date :
February 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2016
Estimated Enrollment :
119 Patients enrolled
Trial Details
Trial ID
NCT01878266
Start Date
February 1 2013
End Date
May 1 2016
Last Update
August 9 2021
Active Locations (1)
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1
Children's Cancer Hospital Egypt 57357
Cairo, Egypt, 11441