Status:
COMPLETED
Exercise Effects in Huntington's Disease
Lead Sponsor:
University of Zurich
Conditions:
Huntington's Disease
Eligibility:
MALE
30-60 years
Phase:
NA
Brief Summary
Huntington's disease (HD) is an incurable and fatal disorder characterised by progressive degeneration of the basal ganglia and the cerebral cortex. Contrary to earlier thinking, HD is associated with...
Detailed Description
Huntington disease (HD) is an incurable and fatal disorder that affects muscle function and leads to cognitive decline and dementia. HD was long considered a brain disorder but meanwhile it was shown ...
Eligibility Criteria
Inclusion
- Inclusion criteria: Inclusion criteria for HD subjects are:
- Male gender
- Genetically verified diagnosis of HD
- Age 30 to 50 years
- Presence of only mild to moderate neurological, cognitive or muscular impairment allowing the subjects to give their written informed consent and to participate in the endurance training (UHDRS 30 or lower)
- For healthy control participants, inclusion criteria are:
- male gender 9
- age 30 to 50 years
- absence of physical or mental illness
- Exclusion criteria: Exclusion criteria for HD subjects are:
- Female gender
- Advanced neurological, cognitive or muscular impairment related to HD that does not allow patients to participate in the endurance training and/or to give their written informed consent
- Cardiovascular disease or any other medical condition that might not be compatible with endurance training
- CK levels \> 300 U/L
- Exclusion criteria for healthy control participants are:
- cardiovascular disease
- any other medical condition that might not be compatible with endurance training
- CK levels \> 300 U/L.
Exclusion
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2018
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01879267
Start Date
January 1 2012
End Date
January 1 2018
Last Update
June 13 2018
Active Locations (1)
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1
University Hospital Zurich, Division of Neurology
Zurich, Canton of Zurich, Switzerland, 8091