Status:
WITHDRAWN
Effect of Catheter-based Radiofrequency Ablation Therapy in Patient With Therapy-resistant Hypertension and Sleep Apnea Syndrome
Lead Sponsor:
University of Zurich
Conditions:
Therapy-resistant Hypertension and Sleep Apnea
Eligibility:
All Genders
18-80 years
Brief Summary
The aim of this prospective single-center study is to evaluate sympathetic nervous system directly measured by microneurography, 24-hour blood pressure, endothelial function, vascular compliance, qual...
Eligibility Criteria
Inclusion
- Inclusion criteria: We plan to include male or female subjects, age 18-80 with a diagnosis of medium-severe sleep apnea syndrome (defined by symptoms, a complaint of excessive daytime sleepiness, an Epworth sleepiness score \>8, and an apnea / hypopnea index \>15/h) and a resistant hypertension (systolic blood pressure \>140 mmHg or \>130 mmHg in patients with type II diabetes or chronic kidney disease, under treatment with three antihypertensive drugs including a diuretic).
- If the selected patients are treated with CPAP, this therapy should be stable during the whole study time.
- Every patient will be asked for a written informed consent.
- Exclusion criteria: - Heart failure (normal ejection fractions on echocardiography and no clinical signs and symptoms of heart failure).
- Long acting nitrates, or PDE-5-Hemmer
- Alcohol or drug abuse,
- Malignancy (unless healed or remission \> 5 years)
- Disease with systemic inflammation (e.g. rheumatoid arthritis, M. Crohn)
- Pulmonary Hypertension (PAP\>50 mmHg)
- Pregnancy
- Anatomical contraindication to renal denervation
- Know allergy to contrast
- Participation in another study within the last month
Exclusion
Key Trial Info
Start Date :
May 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2017
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01879566
Start Date
May 1 2013
End Date
July 1 2017
Last Update
October 25 2017
Active Locations (1)
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1
University Hospital Zurich, Division of Cardiology
Zurich, Canton of Zurich, Switzerland, 8091