Status:
COMPLETED
Evaluation of FLT PET and MRI as Imaging Biomarkers of Early Treatment Response in Patients With Glioblastoma
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
Barnes-Jewish Hospital
Conditions:
Glioblastoma
Eligibility:
All Genders
18+ years
Brief Summary
Glioblastoma is the most common primary malignant neoplasm of the adult brain. Even after multimodal therapy, outcomes remain poor, with a median survival of one year. Although advanced imaging method...
Detailed Description
Patients with glioblastoma will be imaged with FLT PET/CT followed by MRI. The FLT uptake will be correlated with advanced MRI markers of tumor progression to determine the ability of using FLT PET an...
Eligibility Criteria
Inclusion
- Adult patients (\> 18 yo) with a pathological diagnosis of malignant glioma (WHO grades III and IV, including all histological subtypes)
- Surgical intervention includes subtotal resection or biopsy with MRI evidence of residual disease after resection
- Patients with plan to undergo standard chemotherapy and radiation protocols including a combination of fractionated radiation and temozolomide
- Preoperative Karnofsky performance score (KPS) of \> 60
- Willingness of patient and his/her partner to use contraceptive measures for duration of trial that will include PET studies.
Exclusion
- Patient refuses adjunctive therapy
- Pregnancy
- Karnofsky scale \< 60
- Inability to undergo MR imaging studies
- Estimated GFR ≤ 60 ml/min (using GFR = 0.85\*\[140 - age(y)\]\*\[bodyweight(kg)\]/\[72\*Cr(mg/dl)\] for women and GFR = \[140 - age(y)\]\*\[bodyweight(kg)\]/\[72\*Cr(mg/dl)\] for men).
- Inability or unwillingness to follow instructions for both PET and MR imaging sessions.
Key Trial Info
Start Date :
April 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2012
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT01880008
Start Date
April 1 2008
End Date
August 1 2012
Last Update
June 18 2013
Active Locations (1)
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1
Washington University School of Medicine/Barnes-Jewish Hospital
St Louis, Missouri, United States, 63110