Status:
COMPLETED
Effect of the Diet on Urinary Excretion of Alpha-ketoglutarate
Lead Sponsor:
Michel Burnier
Conditions:
Acid Base Disorder
Eligibility:
All Genders
18-44 years
Phase:
NA
Brief Summary
* The G coupled-protein receptors 99 (GPR99) was discovered in 2002 by Wittenberg et al. and is involved as a metabolic receptor. It has been shown that the natural ligand of GPR99 is an intermediate ...
Eligibility Criteria
Inclusion
- healthy person
- Age \>or= 18, \<45
- Caucasian
- Non-smoker
- BMI \>or= 18, \<25
- normal physical examination
- normal ECG 12 pistes
- systolic blood pressure \<or= 139 mmHg and diastolic blood pressure \<or= 89 mmHG (after 5 minutes lying, 3 measures a 2-minutes interval, left arm)
- Heart rate \<or= 90
- Person can understand the written information and the written consent
- Person gave his/her written consent with date and signature before the start of the study
- Urinary pH \> or = 6.5 in the fist urine of the day ( for vegetarian / vegan volunteers only)
Exclusion
- vegetarian or vegan diet ( for omnivorous volunteers only)
- electrolytic disorder defined by Na, K, total calcium, phosphate out of the reference's values of laboratory
- seropositive for HIV, HBV or HCV
- Positive for drugs detected in urine (opiates, cannabinoids, cocaine, benzodiazepines, amphetamines, barbiturates)
- fall of systolic or diastolic blood pressure \> 10mmHg after one minute standing or all other postural hypotension
- any clinically significant disease or condition at gastrointestinal, respiratory, psychiatric, neurological, renal, hepatic, cardiac and other physical sign abnormality which can interfere with the study
- Pregnant during the screening
- current participation or less than 60 days before the screening to another investigational study
- chronic use of any drug during the 4 weeks preceding the inclusion visit (paracetamol excepted)
- donation of blood, platelets, plasma or bone marrow within 3 months preceding the inclusion visit
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2015
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT01880281
Start Date
June 1 2013
End Date
July 1 2015
Last Update
July 31 2019
Active Locations (1)
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1
Service de néphrologie, Centre Hospitalier Universitaire Vaudois
Lausanne, Canton of Vaud, Switzerland, 1011