Status:
COMPLETED
Splanchnic Blood Redistribution After Incretin Hormone Infusion and Obesity Surgery
Lead Sponsor:
Turku University Hospital
Collaborating Sponsors:
Lund University
Conditions:
Type 2 Diabetes
Obesity
Eligibility:
All Genders
18-60 years
Phase:
PHASE1
Brief Summary
Obesity is a worldwide problem and leads to multiple metabolic and endocrinological problems. Bariatric surgeries are a growing field as a treatment choice for morbid obesity (BMI \> 35 kg/m2). Clini...
Detailed Description
Obesity is a worldwide problem and leads to multiple metabolic and endocrinological problems, including type 2 diabetes mellitus (T2DM). In T2DM, body is unable to response to circulating insulin leve...
Eligibility Criteria
Inclusion
- BMI \> 35 kg/m2
- Type 2 diabetes mellitus (fasting glucose more than 7 mmol/l)
- Age: 18-60 years
- Previous, carefully planned, conservative treatments for obesity have failed
Exclusion
- BMI over 60 kg/m2
- Weight more than 170 kg
- Waist circumference \> 150 cm
- Insulin treatment requiring type 2 diabetes mellitus
- Mental disorder or poor compliance
- Eating disorder or excessive use of alcohol
- Active ulcus-disease
- Pregnancy
- Past dose of radiation
- Presence of any ferromagnetic objects that would make MR imaging contraindicated
- Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
- Inclusion criteria for the control group
- BMI 18-27 kg/m2
- Age 18-60 years
- Fasting plasma glucose less than 6.1 mmol/l
- Normal glucose tolerance test (OGTT)
- Exclusion criteria for the control group
- Blood pressure \> 140/90 mmHg
- Any chronic disease
- Mental disorder or poor compliance
- Any chronic medical defect or injury which hinder/interfere everyday life
- Eating disorder or excessive use of alcohol
- Pregnancy
- Past dose of radiation
- Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
- Presence of any ferromagnetic objects that would make MR imaging contraindicated
- Smoking
Key Trial Info
Start Date :
January 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2016
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT01880827
Start Date
January 1 2013
End Date
January 1 2016
Last Update
October 20 2021
Active Locations (1)
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1
Turku univercity hospital, PET center
Turku, Finland, 20540