Status:
TERMINATED
Imaging Tumor Hypoxia With 18F-EF5 PET in Recurrent or Metastatic Clear Cell Ovarian Cancer
Lead Sponsor:
British Columbia Cancer Agency
Collaborating Sponsors:
Carraressi Foundation OVCARE
Conditions:
Ovarian Cancer
Ovarian Neoplasms
Eligibility:
All Genders
19+ years
Brief Summary
The purpose of this study is to use 18F-EF5 PET/CT scans to locate areas with low oxygen levels (hypoxia) in patients with recurrent and/or metastatic cancer.
Detailed Description
This study involves one visit to the BCCA - Vancouver Centre to undergo one EF5-PET/CT scan. The visit will take about 4 hours to complete and no follow-up visits are required. * Participants will fi...
Eligibility Criteria
Inclusion
- Histologically confirmed, advanced metastatic or recurrent clear cell cancer of the ovary
- At least one index lesion measuring 2 cm in diameter
- Must be able to provide written informed consent, and willing to comply with protocol procedures of the study
- Off all active therapy for at least 4 weeks (cytotoxic chemotherapy, radiation, immune therapy, hormone therapy, clinical trials or new agents)
Exclusion
- Renal failure (eGFR \< 50mls/min)
- Patients with unknown primaries
- Previous history of cancer, except treated non-melanoma skin cancer, non-invasive breast cancer, non-invasive cervical cancer; or curatively treated solid cancer with no evidence of recurrence for more than 5 years.
- Receiving or had received active therapy in the form or chemotherapy or radiation within 4 weeks of the PET scan
- ECOG status ≥ 3
- Unable to tolerate a PET scan which involves an injection of radiopharmaceutical and lying flat and still for 30 minutes.
- Weight more than 204.5 kg (Physical Limitation of Imaging and Radiotherapy Couches) or cannot fit through the PET/CT machine (diameter 70cm).
- Patient is pregnant or breastfeeding
Key Trial Info
Start Date :
August 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2020
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT01881451
Start Date
August 1 2013
End Date
May 1 2020
Last Update
February 17 2022
Active Locations (1)
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1
BC Cancer Agency - Vancouver Centre
Vancouver, British Columbia, Canada, V5Z 4E6