Status:
COMPLETED
Postoperative Neuroinflammation and Cognitive Dysfunction After Abdominal Surgery
Lead Sponsor:
Karolinska University Hospital
Collaborating Sponsors:
University of Copenhagen
Conditions:
Anesthesia
Surgery
Eligibility:
All Genders
60-75 years
Phase:
PHASE4
Brief Summary
The main purpose of this study is to assess the induction of neuroinflammation in brain regions of interest for learning and memory in adult patients undergoing urological surgery under general anesth...
Detailed Description
The investigators aim to study immune cell activation as a biomarker for neuroinflammation using the cell specific \[11C\]PBR28 probe as detected by PET imaging techniques.
Eligibility Criteria
Inclusion
- Patients 60-75 years of age. American Society for Anesthesiologist' criteria (ASA) physical status I-III
- Lower abdominal surgery (hysterectomy/prostatectomy) under general anaesthesia
- Obtained consent within 3 months before execution of the study.
Exclusion
- Patient's refusal to participate in the trial
- Ongoing smoking, snuff or other nicotine compound treatment
- Disabling neuropsychiatrical disorder (a Mini mental State Examination (MMSE) score ≤ 24, diagnosis of dementia, Mb Alzheimer, Mb Parkinson, schizophrenia, or mental depression) or other signs of significant cognitive decline.
- History of stroke with neurological sequelae
- Surgical procedure scheduled for regional anaesthesia.
- Severe cardia and/or renal and/or hepatic impairment.
- Coagulopathy.
- Terminal phase of a chronic disease.
- Patient on steroidal or non-steroidal anti-inflammatory drugs.
- Admission B-Glucose \> 15 mmol/litre or poorly controlled diabetes mellitus.
- Presumed uncooperativeness or legal incapacity.
- Preoperative or later postoperative B-hemoglobin \< 90 g/L.
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2016
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT01881646
Start Date
June 1 2013
End Date
February 1 2016
Last Update
January 11 2017
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