Status:
COMPLETED
Proof of Concept of an Anaplerotic Study Using Brain Phosphorus Magnetic Resonance Spectroscopy in Huntington Disease
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Huntington Disease
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this project is to study the efficacy of an anaplerotic treatment on brain energy profile evolution at an early stage of the Huntington disease.
Eligibility Criteria
Inclusion
- 5 \< UHDRS \< 50
- Age \> 18 years
- Ability to undergo MR scanning
- Covered by french social security
Exclusion
- Evidence of psychiatric disorder
- Attendant neurological disorder
- Contraindications to MRI (claustrophobia, metallic or material implants)
- Severe head injury
- Unable to understand the protocol
- Pregnancy
- Failure to give informed consent
- Subjects with exclusion criteria required by french law (e.g. subjects who require a legally authorized representative to obtain consent)
- Unwillingness to be informed in case of abnormal MRI
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT01882062
Start Date
May 1 2013
End Date
July 1 2013
Last Update
March 24 2016
Active Locations (1)
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1
Brain and Spine Institute
Paris, France, 75013