Status:
COMPLETED
Effect of Aerobic Interval Training on Cardiovascular Function in Aging
Lead Sponsor:
University of Florida
Conditions:
Aging
Eligibility:
All Genders
18-79 years
Phase:
NA
Brief Summary
Study objectives: 1. To compare cardiovascular function in older compared to young healthy adults. 2. To compare the effect of 8 weeks of aerobic interval training vs. continuous moderate exercise on...
Detailed Description
Cardiovascular function will be measured at baseline in older healthy adults and young healthy controls. Older adults will be randomized to the aerobic interval training group, continuous moderate exe...
Eligibility Criteria
Inclusion
- Inclusion Criteria for older adults:
- Healthy men and women 55 to 79 years of age
- Sedentary or minimally physically active for at least the prior 1 year.
- Women will be premenopausal or postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years.
- Premenopausal women will be eumenorrheic and will be studied during the early follicular phase (days 1 through 6) of the menstrual cycle.
- Able to give consent.
- Inclusion Criteria for young adults:
- Healthy men and women 18 to 35 years of age
- Sedentary or minimally physically active for at least the prior 1 year.
- Women will be premenopausal, eumenorrheic and will be studied during the early follicular phase (days 1 through 6) of the menstrual cycle.
- Able to give consent.
- Exclusion Criteria:
- history of diabetes
- history of any relevant cardiovascular diseases (myocardial infarction, angina pectoris, history of coronary artery bypass surgery or angioplasty, congestive heart failure, or arrhythmia)
- hypertension (≥160 mmHg systolic or ≥100 mmHg diastolic)
- history of renal impairment
- history of gout or hyperuricemia
- history of hepatic disease or infection with hepatitis B, C
- history of seizures, or other relevant on-going or recurrent illness
- recent (within 3 months) or recurrent hospitalizations
- use of tobacco products
- \>5 % weight change in the prior 6 months.
- current intake of medications that may affect study results
- participation in regular aerobic exercise training (\>30 minutes,
- 3 times/wk in the past year).
- premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy.
- pregnancy (positive urine pregnancy test) or lactation
Exclusion
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 21 2019
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01883271
Start Date
May 1 2013
End Date
February 21 2019
Last Update
February 25 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Florida
Gainesville, Florida, United States, 32611