Status:
COMPLETED
Study of Methemoglobin as a Biomarker of Tissue Hypoxia During Acute Hemodilution in Heart Surgery Patients
Lead Sponsor:
Unity Health Toronto
Conditions:
Other Functional Disturbances Following Cardiac Surgery
Eligibility:
All Genders
18-65 years
Brief Summary
Acute and chronic anemia continue to be associated with increased mortality in a number of clinical settings, including cardiac and non-cardiac surgery. However, "We have no clinical measures that let...
Detailed Description
Acute and chronic anemia continue to be associated with increased mortality in a number of clinical settings, including cardiac and non-cardiac surgery. 1-6 However, as recently stated by one of the p...
Eligibility Criteria
Inclusion
- patients undergoing heart surgery using cardiopulmonary bypass at St. Michael's Hospital who have a pre-operative Hb value greater than 90 g/L, no evidence of hypoxemia (SaO2 \> 90%) and no history of congenital methemoglobinemia.
Exclusion
- severe hypoxemia, acute or chronic renal failure requiring dialysis, emergency surgery or the lack of a PA catheter (current standard of care at St. Michael's Hospital is to insert a PA catheter in \> 90% of patients).
Key Trial Info
Start Date :
January 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2016
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT01883713
Start Date
January 1 2013
End Date
August 1 2016
Last Update
April 17 2018
Active Locations (1)
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1
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8