Status:
RECRUITING
Hormonal, Metabolic, and Signaling Interactions in PAH
Lead Sponsor:
Vanderbilt University Medical Center
Conditions:
Idiopathic Pulmonary Arterial Hypertension
Heritable Pulmonary Arterial Hypertension
Eligibility:
All Genders
Up to 90 years
Brief Summary
Our hypothesis is that optimal treatment of the dysfunctional metabolic pathways which underlie PAH will improve pulmonary vascular function and consequences of the disease.
Detailed Description
Project 1: This project will work to understand why women are affected by pulmonary arterial hypertension (PAH) so much more often than men. This observation is true in heritable, idiopathic and assoc...
Eligibility Criteria
Inclusion
- Project 1
- Inclusion:
- Diagnosis of IPAH (idiopathic pulmonary arterial hypertension), HPAH (heritable pulmonary arterial hypertension), or APAH (associated pulmonary arterial hypertension), family members of affected persons
- Age 0-90, age 12-90 for skin biopsy
- Exclusion:
- Other diagnosis
- Age greater than 90, age less than 12 or greater than 90 for skin biopsy
- Project 2
- Inclusion:
- Diagnosis of IPAH, HPAH, or APAH, family members of affected persons
- 0-90
- Subjects with reasonably easy access to clinic for blood collection and other testing
- Subject able to tolerate fasting state prior to sample collection and EndoPAT (endothelial function assessment) testing
- Exclusion:
- Other diagnosis
- 0-90
- Subjects with difficulty reaching clinic for blood collection and other testing
- Subjects unable to tolerate fasting state
- Project 3
- Inclusion:
- Diagnosis of IPAH, HPAH, or APAH, family members of affected persons
- 7-90
- Exclusion:
- Other diagnosis
- Age less than 7 or greater than 90
- \-
Exclusion
- \-
Key Trial Info
Start Date :
September 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2032
Estimated Enrollment :
1899 Patients enrolled
Trial Details
Trial ID
NCT01884051
Start Date
September 1 2012
End Date
July 1 2032
Last Update
September 16 2025
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232