Status:
COMPLETED
Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis
Lead Sponsor:
McMaster University
Conditions:
Muscle Protein Synthesis
Eligibility:
MALE
18-35 years
Phase:
NA
Brief Summary
Muscle mass is normally maintained through the regulated balance between the processes of protein synthesis (i.e. making new muscle proteins) and protein breakdown (breaking down old muscle proteins)....
Detailed Description
The processes of muscle protein synthesis (MPS) and muscle protein breakdown (MPB) occur concurrently. This constant protein turnover allows the muscle fiber to change its protein structure if loading...
Eligibility Criteria
Inclusion
- Male
- Healthy and physically active (as determined by medical and activity questionnaire)
- 18-35 years of age
- 70-90 kg body mass
- Having given informed consent
Exclusion
- Exhibiting health risk factors as identified on the health screening questionnaire
- Having any identified metabolic or intestinal disorders
- Tobacco use
- Aspirin use in the 4 days prior to the experimental trial
- Consumption of prescription medications or any performance enhancing agent
- Inability to endure the strenuous exercise bouts e.g. injuries
- Alcohol intake during the 48 hours prior to each of the testing days
- Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study
- Have given blood in the last three weeks
- Verbal confirmation that they have used a substance on the WADA banned list within the last year
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2011
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01885429
Start Date
January 1 2011
End Date
May 1 2011
Last Update
July 30 2013
Active Locations (1)
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1
McMaster University
Hamilton, Ontario, Canada, L8S 4K1