Status:
COMPLETED
Mechanical Ventilation in Brain-injured Patients
Lead Sponsor:
Nantes University Hospital
Conditions:
Brain-injury
Stroke
Eligibility:
All Genders
18+ years
Brief Summary
Protective ventilation (association of a tidal volume \< 8 ml/kg with a positive end expiratory pressure) is poorly used in severe brain-injured patients. Moreover, a systematic approach to extubation...
Detailed Description
A before/after study design will be used. The before period (control phase) will consisted of all consecutive patients with severe brain-injury who were admitted to the participating ICUs. During the...
Eligibility Criteria
Inclusion
- Adult patients (traumatic brain-injured, subarachnoid hemorrhage, stroke or other)
- Brain injury (Glasgow Coma Scale ≤ 12 associated with at least one anomaly related to an acute process on head tomographic tomodensitometry
- mechanical ventilation for more than 24 hours
Exclusion
- early decision to withdraw care (taken in the first 24 hours in ICU),
- death in the first 24 hours
Key Trial Info
Start Date :
July 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2014
Estimated Enrollment :
560 Patients enrolled
Trial Details
Trial ID
NCT01885507
Start Date
July 1 2013
End Date
September 1 2014
Last Update
February 23 2015
Active Locations (22)
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1
Angers University Hospital
Angers, France
2
Beaujon Hospital
Beaujon, France
3
Brest University Hospital
Brest, France
4
Caen University Hospital
Caen, France