Status:
TERMINATED
The Addition of Non-Invasive Ventilation To Airway Clearance Techniques In Adults With Cystic Fibrosis
Lead Sponsor:
Royal Brompton & Harefield NHS Foundation Trust
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
16+ years
Phase:
NA
Brief Summary
Cystic Fibrosis (CF) is a genetic disorder of altered ion transport across cell membranes which is characterised by the production of thickened bodily secretions, affecting the function of organs such...
Detailed Description
Cystic Fibrosis (CF) is a genetic disorder of altered ion transport across cell membranes which is characterised by the production of thickened bodily secretions, affecting the function of organs such...
Eligibility Criteria
Inclusion
- Diagnosis of cystic fibrosis (confirmed by genotype or a sweat sodium concentration of \>70mmol/l or sweat chloride of \>60mmol/l)
- Sixteen years of age or over
- Patients admitted to the Royal Brompton Hospital with a pulmonary exacerbation of which is resolving. Patients will be considered for inclusion from day 7 of treatment to 3 days prior to discharge (as determined by a member of the cystic fibrosis medical team and have spirometric values within 20% of the mean of the last two stable recordings (at least 1 month apart)
- Patients with an established airway clearance regime that they have used for 3 months or more
Exclusion
- Current moderate haemoptysis (greater than streaking in the sputum)
- Current pneumothorax or history of pneumothorax in the 3 months prior to consideration for the study
- Current dependency on positive pressure support with airway clearance via the IPPB (Intermittent Positive Pressure Breathing) machine or NIV
- Previous history of spontaneous rib fractures
- Pregnancy
- Inability to give consent for treatment or measurement
- Current participation in another study
- If the patient requires more than 2 airway clearance sessions a day
Key Trial Info
Start Date :
July 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 11 2017
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT01885650
Start Date
July 1 2013
End Date
May 11 2017
Last Update
August 2 2017
Active Locations (1)
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1
The Royal Brompton Hospital
London, Greater London, United Kingdom, SW3 6NP