Status:
COMPLETED
Efficacy of Proton Pump Inhibitor for Chronic Cough Caused by Gastroesophageal Reflux; Double-blind, Placebo-controlled, Randomized Clinical Trial
Lead Sponsor:
Yonsei University
Conditions:
Chronic Cough Caused by Gastroesophageal Reflux
Eligibility:
All Genders
19-70 years
Phase:
NA
Brief Summary
Efficacy of proton pump inhibitor for chronic cough caused by gastroesophageal reflux; double-blind, placebo-controlled, randomized clinical trial
Eligibility Criteria
Inclusion
- ages of 18 and 70 years had chronic cough of \>8 weeks in duration
Exclusion
- 1\. abnormal chest X ray, PNS view 2. previous surgical or endoscopic antireflux procedure 3. previous aerodigestive malignancy or Barrett's oesophagus 4. current smokers or ex-smok-ers (defined as those who quit smoking \<3 months prior to study enrolment or those who have quit, but have a 20 pack year smoking history) 5. Malignancy History (lung cancer, esophageal cancer etc.) 6. upper respiratory infection within 8 weeks of study enrolment 7. currently using a PPI, H2 blocker, beta-blocker, angiotensin-converting enzyme inhibitor, corticosteroid, methylxanthine, inhaled beta-agonist, anti-inflammatory agent or anticholinesterase drug at time of enrolment
Key Trial Info
Start Date :
February 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2016
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT01888549
Start Date
February 1 2012
End Date
February 1 2016
Last Update
June 24 2016
Active Locations (1)
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1
Gangnam severance hospita
Seoul, Seoul, South Korea, 120-752