Status:
COMPLETED
Methionine Metabolism in Enterally Fed Pediatric Sepsis
Lead Sponsor:
The Cleveland Clinic
Conditions:
Sepsis
Critical Illness
Eligibility:
All Genders
1-19 years
Brief Summary
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Protein synthesis is increased mainly in the form of immune and signaling proteins, while muscle and...
Detailed Description
This is a prospective, translational study on the splanchnic metabolism of methionine to determine the rates of the different pathways and synthesis rates of glutathione when critically ill children a...
Eligibility Criteria
Inclusion
- Children age 1 month-19 years
- Diagnosis of severe sepsis diagnosed as clinical sepsis syndrome (requires two of the following criteria):
- Source of infection
- Fever or Hypothermia
- Leukocytosis or Leucopenia
- Poor organ perfusion (such as delayed capillary refill or decreased urine output or hypotension)
- Bacteremic sepsis demonstrated by positive blood culture
- Weight greater or equal to 4.0 kg
- Need for enteral nutrition by a nasogastric/nasoduodenal tube
- Presence of central and/or arterial venous access as per clinical indication
Exclusion
- Patients with metabolic diseases (i.e. Insulin dependent diabetes mellitus, urea cycle disorders, cystinuria, etc.)
- Pregnancy
- Primary liver failure
- Primary renal failure
- Patients unable to tolerate enteral feedings
- Weight less than 4.0 kg
Key Trial Info
Start Date :
December 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2016
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT01889264
Start Date
December 1 2011
End Date
October 1 2016
Last Update
March 22 2017
Active Locations (1)
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1
Cleveland Clinic
Cleveland, Ohio, United States, 44195