Status:
UNKNOWN
The Effects of the Food Preservative Propionic Acid in Post-prandial Metabolism
Lead Sponsor:
Brigham and Women's Hospital
Conditions:
Obesity
Insulin Resistance
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Propionic acid (PA) is used as a preservative in foods such as cheeses, baked goods, or additive for artificial fruit flavors. The U.S. Environmental Protection Agency considers it safe and therefore,...
Detailed Description
-To test whether PA, added as food supplement to humans, results in altered post-prandial metabolism. The investigators propose to conduct a double-blind, randomized, placebo controlled, cross-over st...
Eligibility Criteria
Inclusion
- Age 18-65 years
- Good health as evidenced by history and physical exam
- BMI: 20-29.9 kg/m2
Exclusion
- Fasting plasma glucose \>110 mg/dL
- HbA1c \>6.0%
- Significant current illness other than treated hypothyroidism
- BP \>135/85 or systolic BP \<90 mm Hg
- Hepatic disease (transaminase \> 3 times normal)
- Renal impairment (Creatinine clearance \<60 ml/min)
- History of drug or alcohol abuse
- Participation in any other concurrent clinical trial
- Pregnant women
- History of food allergies.
Key Trial Info
Start Date :
August 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2015
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01889446
Start Date
August 1 2013
End Date
June 1 2015
Last Update
September 22 2014
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115