Status:
WITHDRAWN
Vitamin D + Telaprevir + Peginterferon + Ribavirin for of Hepatitis C Genotype 1
Lead Sponsor:
Timothy Morgan, MD
Collaborating Sponsors:
Vertex Pharmaceuticals Incorporated
Conditions:
Hepatitis C
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
This study is for people who have been diagnosed with chronic hepatitis C, specifically those who have a certain type of the virus, genotype 1, and who have not yet received treatment for hepatitis C....
Eligibility Criteria
Inclusion
- Chronic Hepatitis C genotype 1 infection
- Treatment naïve
- Age \>18 years
- Agree to genetic testing
Exclusion
- Liver disease other than from hepatitis C
- HCV infection with mixed genotypes
- Decompensated liver disease
- AFP\>100ng/ml.
- Known HIV infection
- Serum 25(OH)D less than 12ng/ml or greater than 30ng/ml
- Regular vitamin D supplement use
- Regular calcium supplement use
- Refusal to abstain from vitamin D supplementation
- Current or past history of kidney stones
- Current use of any of the prohibited medications listed in section 5.5 and the INCIVEK® package insert.
- Need for therapeutic vitamin D or calcium (e.g. treatment for osteoporosis, osteomalacia, hyperparathyroidism etc.), in the opinion of the investigator
- Significant substance abuse within the past 6 months,
- Suicidal attempt in the past 10 years or suicidal ideation in past 3 months, or any other psychiatric condition that the investigator deems would make a subject unsuited for treatment with peginterferon or ribavirin.
- Confirmed or suspected malignancy, or history of malignancy within the past 3 years (except treated basal cell carcinoma of the skin or in situ carcinoma of the uterine cervix)
- Any autoimmune disease not easily controlled (in the opinion of the investigator)
- Any condition resulting in malabsorption (
- Poorly controlled thyroid disorder, or diabetes mellitus (HbA1c \> 9)
- Glomerular diseases (e.g., glomerulosclerosis or glomerulonephritis) associated with a serum creatinine \>1.5 times the upper limit of normal
- Current or history of any clinically significant cardiac abnormalities/dysfunction (eg, angina, congestive heart failure, myocardial infarction, pulmonary hypertension, complex congenital heart disease, cardiomyopathy, significant arrhythmia) including current uncontrolled hypertension or history of use of antianginal agents for cardiac conditions (Inclusion will be considered if clearance by a cardiologist is obtained.)
- Receipt of an investigational drug within the past 30 days
- Females who have a positive pregnancy test at the time of screening, are breastfeeding or who anticipate pregnancy within the next 18 months, or men with pregnant partners
- Lack of agreement from subject to use two forms of acceptable contraception
- History or other evidence of any significant illness which, in the opinion of the investigator, would make the patient, unsuitable for the study
- Laboratory Exclusions
- Hemoglobin: \<12gm/dl male or female
- Neutrophil: \<1,200/mm3
- Platelets: \<90,000/mm3
- INR: \>1.5
- Albumin: \<3.2gm/dl
- Total Bilirubin: \>2.0mg/dl
- HbA1c: \>9.5%
- Serum Creatinine: \>1.5 times the upper limit of normal
- Serum Calcium Within local laboratory normal range
- Parathyroid hormone (PTH) \<10 or \>55 pg/mL
Key Trial Info
Start Date :
August 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01890772
Start Date
August 1 2013
Last Update
May 14 2014
Active Locations (4)
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1
VA Long Beach Healthcare System
Long Beach, California, United States, 90822
2
Minneapolis VAHCS
Minneapolis, Minnesota, United States, 55417
3
Kansas City VA Medical Center
Kansas City, Missouri, United States, 64128
4
Philadelphia VA Medical Center
Philadelphia, Pennsylvania, United States, 19104