Status:
COMPLETED
Methionine Metabolism in Parenterally Fed Pediatric Sepsis
Lead Sponsor:
The Cleveland Clinic
Conditions:
Sepsis
Critical Illness
Eligibility:
All Genders
1-19 years
Brief Summary
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Protein synthesis is increased mainly in the form of immune and signaling proteins, while synthesis ...
Detailed Description
This is a prospective, translational study on whole body methionine metabolism and requirements when administered by the parenteral route in critically ill septic children. The study size will include...
Eligibility Criteria
Inclusion
- Age 1 month-19 years
- Diagnosis of severe sepsis diagnosed as clinical sepsis syndrome (requires two of the following criteria):
- Source of infection
- Fever or Hypothermia
- Leukocytosis or Leucopenia
- Poor organ perfusion (such as delayed capillary refill or decreased urine output or hypotension)
- Bacteremic sepsis demonstrated by positive blood culture
- Weight greater or equal to 4 kg
- Need for parenteral nutrition
- Presence of central and/or arterial venous access as per clinical indication
Exclusion
- Patients with metabolic diseases (i.e. Insulin dependent diabetes mellitus, urea cycle disorders, cystinuria, etc.)
- Pregnancy
- Primary liver failure
- Primary renal failure
- Patients on enteral feedings greater than 20% of daily requirement
- Weight less than 4.0 kg
Key Trial Info
Start Date :
October 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2016
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT01891682
Start Date
October 1 2012
End Date
October 1 2016
Last Update
March 22 2017
Active Locations (1)
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1
Cleveland Clinic
Cleveland, Ohio, United States, 44195