Status:
UNKNOWN
VEGF Signaling Promotes Cell Growth and Metastasis in Hepatocellular Carcinoma in a VEGF Receptor Mediated Pathway
Lead Sponsor:
First Affiliated Hospital, Sun Yat-Sen University
Collaborating Sponsors:
Guangdong Province, Department of Science and Technology
Conditions:
Hepatocellular Carcinoma
Eligibility:
All Genders
16-80 years
Brief Summary
The investigators study the VEGF signaling in HCC cell lines and its mechanism in HCC growth, proliferation and apoptosis.
Detailed Description
Several studies have documented the elevated expression of VEGF, VEGFR1 and VEGFR2 in HCC cell lines and tumor tissues. Another study observed a sequential elevation of VEGF in low-grade dysplasia, hi...
Eligibility Criteria
Inclusion
- hepatocellular patients diagnosed through biopsy;or either dynamic imagine with a diagnosis of hepatocellular carcinoma and alphafetoprotein\>400μg/L；or two or more dynamic imagine with a diagnosis of hepatocellular carcinoma
- Child-Pugh A or B
- well preserved renal and hematopoietic Function
- receive surgical therapy
- achieve complete section accessed by contrast-enhanced CT
Exclusion
- incomplete section
- remote metastasis
- Child-Pugh C
- combination with other hepatobiliary disease
- suffer from other tumors concurrently or in last five years
Key Trial Info
Start Date :
October 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2014
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01892072
Start Date
October 1 2012
End Date
March 1 2014
Last Update
July 11 2013
Active Locations (1)
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1
First Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, China, 510000