Status:
COMPLETED
Effects of High-dose Coenzyme Q10 on Biomarkers of Oxidative Damage and Clinical Outcome in Parkinson Disease
Lead Sponsor:
National University Hospital, Singapore
Conditions:
Parkinson Disease
Eligibility:
All Genders
21+ years
Phase:
PHASE2
PHASE3
Brief Summary
The investigators hypothesise that measuring biomarkers of oxidative damage could better inform investigators on the potential merits (and pitfalls) of CoQ10 supplementation in PD subjects.
Detailed Description
Subjects with idiopathic PD will be recruited to a 10-week dose escalation study. Each dosage (400mg/day, 800mg/day, 1200/day and 2400mg/day) will be consumed daily for two weeks. Information on safet...
Eligibility Criteria
Inclusion
- idiopathic Parkinson disease
- age \>21 years
- able to provide written informed consent
Exclusion
- diabetes mellitus, stroke, cardiac and renal diseases and cigarette smoking
- major psychiatric disorder or drug and/or alcohol abuse/dependence
- regular use of antioxidants, dietary supplements, traditional Chinese remedies, non-steroidal anti-inflammatory drugs or immunosuppressive drugs
Key Trial Info
Start Date :
June 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01892176
Start Date
June 1 2012
End Date
December 1 2012
Last Update
July 10 2013
Active Locations (1)
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1
National University Health System
Singapore, Singapore, Singapore, 119228