Status:
UNKNOWN
Ketamine for Acute Suicidal Ideation in the Emergency Department: Randomized Controlled Trial
Lead Sponsor:
Brooke Army Medical Center
Conditions:
Suicide
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
This study will enroll patients presenting to the emergency department with acute suicidal ideation meeting inclusion and exclusion criteria. Patients will be randomized to one of three arms: ketamine...
Eligibility Criteria
Inclusion
- Patients age 18 to less than 75 who present to the SAMMC ED with either overt or incidental suicidal ideations with a SADPERSONS score 5 or greater that the treating provider feels warrant formal evaluation.
Exclusion
- -Poor vital sign stability hypoxia: O2 \< 95%, hypotension: SBP\< 90 hypertension: SBP\>180 Heart rate: \< 50 or \>120 Respiratory Rate: \<10 or \>30
- Altered mental status or intoxication
- Patient is unwilling to participate or provide informed consent
- Any allergy to ketamine or diphenhydramine
- Patient is female of child-bearing age and unwilling to provide urine or blood for HCG analysis
- Pregnancy or breast feeding
- Presence of chronic oxygen-dependent pulmonary disease, liver cirrhosis, or renal disease requiring dialysis
- Presence of ischemic heart disease, heart failure, or a history of unstable dysrhythmias
- Presence of intracranial mass or vascular lesion.
- Presence of a history of psychosis or hallucinations (as assessed by electronic chart review)
- Weight greater than 115 kg or less than 45kg
- History of increased intracranial pressure/hypertensive hydrocephalus
- Non-English speaking patients
- Patient is acutely psychotic
- Provider feels that patient currently or likely will require chemical and/or physical restraints
- History of prolonged QT-interval
Key Trial Info
Start Date :
June 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT01892995
Start Date
June 1 2015
Last Update
February 16 2015
Active Locations (1)
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1
Brooke Army Medical Center
Fort Sam Houston, Texas, United States, 78234