Status:
TERMINATED
Study of Whole-brain Irradiation With Chloroquine for Brain Metastases
Lead Sponsor:
Instituto Nacional de Cancerologia de Mexico
Conditions:
Brain Metastasis
Eligibility:
All Genders
46-61 years
Phase:
PHASE2
Brief Summary
Background and purposes:Chloroquine (CLQ), an antimalarial drug, has a lysosomatrophic effect associate with increase the sensibility of Radiation through leakage of hidroliticenzimes, increase of apo...
Detailed Description
Seventy-three eligible patients were randomized. Thirty-nine patients received WBI (30 Gy in 10 fractions over 2 weeks) concomitant with 150 mg of CLQ for 4 weeks (the CLQ group). Thirty-four patients...
Eligibility Criteria
Inclusion
- 18 to 80 years of age
- At leat one brain metastasis MRI
- KPS 70 or more
- RTOG-RPA I or II
- Basic Laboratory requirements
Exclusion
- Candidates for radiosurgery, neurosurgery
- Patients treated with radiotherapy before entered to the study
Key Trial Info
Start Date :
May 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
73 Patients enrolled
Trial Details
Trial ID
NCT01894633
Start Date
May 1 2011
End Date
January 1 2013
Last Update
January 24 2024
Active Locations (1)
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1
Instituto Nacional de Cancerologia
Mexico City, Mexico City, Mexico, 14080