Status:
COMPLETED
PET-MRI After Radiofrequency Ablation (RFA) or Microwave Ablation (MWA)
Lead Sponsor:
dr. M.P. van den Tol MD PhD
Conditions:
Liver Neoplasms
Local Neoplasm Recurrence
Eligibility:
All Genders
18+ years
Brief Summary
The primary objective of this study is to evaluate the ability of PET-MRI and to detect a local site recurrence during the first year of follow-up after RFA or MWA of colorectal liver metastases (CRLM...
Detailed Description
All included patients will routinely undergo follow-up with 3 monthly ceCT of the liver and PET-CT in the first year after RFA/MWA of CRLM according to standard of care in our hospital. Patients are a...
Eligibility Criteria
Inclusion
- Histological or cytological documentation of primary colorectal tumor
- Radiological or histological prove of one or more CRLM or radiological proof of a LSR after previous RFA/MWA treatment for CRLM
- CRLM or LSR treated with RFA/MWA or RFA/MWA in combination with resection
- Follow-up imaging performed in Free University (VU) University Medical Center
- Age ³ 18 years
- Life expectancy of at least 1 year
- estimated glomerular filtration rate (eGFR) \> 60 or hydration according to protocol before scanning
- Written informed consent.
Exclusion
- cirrhosis or steatosis of the liver
- Chemotherapy ≤ 6 weeks before scanning (during the entire study)
- Pregnant or breast-feeding subjects
- Allergy to contrast media
- Patients developing recurrent intrahepatic disease that require resection of the ablated lesion
- eGFR \< 60, unless hydration according to protocol is possible
- General exclusion criteria to undergo MRI
- claustrophobia
- intracranial clips
- any implanted stimulation device (eg. internal cardioverter defibrillator/pacemaker, cochlear implant)
- intra-ocular metal splinters or metal clips
- Metal artificial heart valve
- Bone prosthesis \< 6 weeks
- inability to lie still for 30 minutes
- orthopnea
- intestinal video capsule
- Metal intra auricular prosthesis
- all other prosthesis or piercings should be removed.
Key Trial Info
Start Date :
June 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2016
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01895673
Start Date
June 1 2013
End Date
June 1 2016
Last Update
December 15 2016
Active Locations (1)
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1
VU University Medical Centre
Amsterdam, North Holland, Netherlands, 1081 hv