Status:
COMPLETED
Migraine With Aura Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow by Hypoxia
Lead Sponsor:
Danish Headache Center
Conditions:
Headache
Migraine
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
In this study the investigators will investigate the following hypothesis * that hypoxia induce migraine headache and migraine aura * the aura phase is associated with a spreading reduction in cerebr...
Detailed Description
To investigate migraine with aura symptoms during and after hypoxia. With magnetic resonance imaging the investigators will investigate changes in * regional cerebral blood flow (rCBF) * resting sta...
Eligibility Criteria
Inclusion
- Migraine with aura patients and Helthy volunteers as controls:
- Aged 18-40
- 50-100 kg
Exclusion
- Tension type headache more than 5 days/month
- Other primary headaches
- Daily medication except contraceptives
- Drug taken within 4 times the halflife for the specific drug except contraceptives
- Pregnant or lactating women
- Headache or migraine attack within the last 48 hours before start of trial
- Hypertension
- Hypotension
- Respiratory or cardiac disease
- smoking
- Extra exclusion Criteria for healthy volunteers:
- migraine at present or earlier in life
- parents, sibling or children who suffer or have suffered from migraine
Key Trial Info
Start Date :
April 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2014
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT01896167
Start Date
April 1 2013
End Date
September 1 2014
Last Update
February 12 2015
Active Locations (1)
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1
Nanna Arngrim
Glostrup Municipality, Denmark, 2600