Status:
COMPLETED
Study to Compare the Safety and Efficacy of ALZ-1101 to Latanoprost in Patients With Intraocular Pressure Inadequately Controlled by Latanoprost
Lead Sponsor:
Alleanza Pharmaceuticals, Inc.
Conditions:
Primary Open Angle Glaucoma
Ocular Hypertension
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This is a pilot, proof of concept study to evaluate the safety and efficacy of ALZ-1101 dosed once daily for 28 days compared to latanoprost 0.005% ophthalmic solution in patients with elevated intrao...
Detailed Description
This is an exploratory, pilot, proof of concept Phase 2 study. The objectives include the comparison of efficacy of ALZ-1101 to latanoprost 0.005% ophthalmic solution in reducing elevated intraocular ...
Eligibility Criteria
Inclusion
- Age 18 years or older.
- Primary open-angle glaucoma or OH on treatment with latanoprost 0.005% QD.
- At least one eye with IOP \> 18 mm Hg but ≤ 28 mm Hg at all time points (8 AM, 10 AM, and 4 PM) while on latanoprost monotherapy QD at Screening and Baseline (Day 0) visits. Measurements will be taken each visit at 8 AM, 10 AM, and 4 PM (each ± 30 minutes), with AM measurements of IOP at least 2 hours apart. Screening must be at least one week before but within 2 weeks prior to Baseline.
- On latanoprost 0.005% QD for at least 4 weeks prior to randomization.
- Shaffer gonioscopic grade of ≥ 3 (in at least 3 quadrants) in both eyes.
- Stable corrected Snellen visual acuity (VA) better than 20/200 in the study eye.
- Central corneal thickness between 480-620 μm in the study eye.
- Female subjects must be 1-year postmenopausal, surgically sterilized, or women of childbearing potential with a negative urine pregnancy test at Visit 1. Women of childbearing potential must use an acceptable form of contraception throughout the study. Acceptable methods include the use of at least one of the following: intrauterine (intrauterine device), hormonal (oral, injection, patch, implant, ring), barrier with spermicide (condom, diaphragm), or abstinence.
- Provide signed written consent prior to participation in any study-related procedures.
Exclusion
- A mean deviation of \< -20 dB on visual field (VF) assessment.
- Presence of a scotoma within 5°of fixation on VF.
- Aphakia.
- Use of any antiglaucoma medication in addition to latanoprost QD within 2 weeks prior to Visit 1 or during the study period.
- Use of any topical ophthalmic steroid or nonsteroidal anti-inflammatory drug (NSAID) within 2 weeks prior to Visit 1 or during the study period.
- Use of systemic carbonic anhydrase inhibitor within 2 weeks prior to Visit 1 or during the study period.
- Ocular surgery or ocular laser treatment of any kind within 3 months prior to Visit 1 or during the study period.
- Any history of glaucoma surgery (laser or non-laser).
- History of ocular allergy/inflammation and/or severe blepharitis and/or uveitis. Seasonal allergic conjunctivitis is acceptable (avoid enrollment of subjects who may experience seasonal flare-up during the study period). Mild blepharitis/blepharoconjunctivitis, typically associated with prostaglandin usage, is acceptable.
- History of ocular trauma or ocular infection within 3 months of Visit 1.
- History of herpes simplex keratitis.
- Current proliferative diabetic retinopathy or age-related macular degeneration, unless deemed not clinically significant by the Investigator.
- Severe dry eye (eg, clinically relevant superficial punctate keratitis, epithelial erosions of the cornea, and/or use of dry eye medication \[including artificial tears\] with a frequency exceeding 8 applications per day).
- Contact lens wear within one week prior to Visit 1 or during the study period (contact lens wear in an untreated fellow eye is allowed).
- Angle closure or occludable angles (Shaffer gonioscopic grade of \< 3).
- Cataract that compromises visualization of the fundus.
- Cup-to-disc (C/D) ratio of \> 0.8.
- Any secondary glaucoma or OH (eg, congenital glaucoma, closed-angle glaucoma, uveitic glaucoma, or pseudoexfoliation syndrome).
- Pregnancy or lactation.
- Uncontrolled asthma (defined as asthma that does not respond to the maximum guideline directed therapy).
- Allergy to prostaglandin analogues or carbonic anhydrase inhibitors.
- Allergy to benzalkonium chloride.
- History of moderate or severe renal or hepatic impairment.
- Participation in any study of an investigational product within 30 days prior to Visit 1 or at any time during the study period.
Key Trial Info
Start Date :
July 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2014
Estimated Enrollment :
63 Patients enrolled
Trial Details
Trial ID
NCT01896180
Start Date
July 1 2013
End Date
January 1 2014
Last Update
September 30 2014
Active Locations (1)
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1
Morrow, Georgia, United States