Status:
COMPLETED
Effect of Antihypertensive Agents Over Sleep Apnea
Lead Sponsor:
Hospital de Clinicas de Porto Alegre
Conditions:
Hypertension
Obstructive Sleep Apnea
Eligibility:
All Genders
40+ years
Phase:
PHASE3
Brief Summary
Obstructive sleep apnea and hypertension are well-known cardiovascular risk factors. Their control could reduce the burden of heart disease across populations. There are several drugs to control hyper...
Detailed Description
This is a randomized, double-blind, clinical trial, comparing the association of Chlorthalidone plus amiloride 25 and 5 mg daily, versus amlodipine 10 mg daily as first drug option in patients older t...
Eligibility Criteria
Inclusion
- Patients older than 40 years of age
- Stage I hypertension (140-159/90-99 mmHg) and moderate obstructive sleep apnea (10-40 apneas/hour of sleep)
Exclusion
- Low life expectancy
- Other indications for the use of diuretics or calcium channel blocker -Intolerance or contraindications to the study drugs
- Pregnancy
- Established cardiovascular disease (myocardial infarction
- Stroke
- Heart failure)
- Use of more than one drug for hypertension
- Secondary hypertension
- Participation in other clinical trial in previous 6 months
Key Trial Info
Start Date :
December 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2016
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT01896661
Start Date
December 1 2014
End Date
February 1 2016
Last Update
July 14 2016
Active Locations (1)
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1
Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil, 90035-903