Status:
COMPLETED
Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.
Lead Sponsor:
Pontificia Universidad Catolica de Chile
Conditions:
Hypertensive Disease
Pain, Postoperative
Eligibility:
All Genders
20-60 years
Phase:
PHASE4
Brief Summary
The purpose of this randomized clinical trial is to evaluate the effect of acute arterial hypertension maintained during surgery on morphine's requirements in patients undergoing laparoscopic cholecys...
Detailed Description
The high arterial blood pressure has been correlated with an increase in pain threshold in animal and humans. One of the explanations to this phenomenon is a baroreceptor activity and vasopressin rele...
Eligibility Criteria
Inclusion
- American Society of Anesthesiology patient classification status(ASA) I-II
- Between 20 and 60 years of age
- Programed for elective laparoscopic cholecystectomy
Exclusion
- History of arterial hypertension
- Baseline blood pressure over 139/89
- Use of opioids and any analgesic drug during the last 24 hours before surgery
- Chronic use of nonsteroidal antiinflammatory
- BMI \> 34.9
- History of drug or alcohol abuse
- Use of medications that interfere in the central nervous system
- Adverse reactions to the drugs used in the study
- Pregnancy
Key Trial Info
Start Date :
January 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01897155
Start Date
January 1 2010
End Date
January 1 2012
Last Update
July 11 2013
Active Locations (1)
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1
Hospital Clinico Pontificia Universidad Catolica
Santiago, Santiago Metropolitan, Chile, 8330024