Status:
COMPLETED
The Impact of Helicobacter Pylori Infection on Immune Regulation and Clinical Course in HIV Patients in Ghana
Lead Sponsor:
Bernhard Nocht Institute for Tropical Medicine
Collaborating Sponsors:
Kwame Nkrumah University of Science and Technology
Kumasi Centre for Collaborative Research (KCCR)
Conditions:
HIV
Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Eligibility:
All Genders
18+ years
Brief Summary
The main objective of the study is to investigate the impact of H. pylori infection on immune activation and clinical outcome in HIV patients. Other specific study objectives are: 1. To investigate ...
Detailed Description
Study design: Observational case control study with longitudinal follow up Recruitment: 1000 HIV patients regularly attending to the KATH HIV clinic will be screened for H. pylori infection and oth...
Eligibility Criteria
Inclusion
- able and willing to give informed written consent
- age \> 18 years
- CD4 cells \>350/µl
Exclusion
- not willing or able to comply with study procedures
- HIV2 or HIV1/2 co-infection
- Active opportunistic infection or other acute systemic infection (e. g. pneumonia) or malignancy ( e. g. lymphoma)
- Anti-helminth or anti helicobacter pylori treatment in the past 6 months
- Anemia (Haemoglobin \< 7 g/dl)
- Active systemic or opportunistic infection or tumor (e. g. pneumonia, tuberculosis)
- Patient is on highly active antiretroviral therapy (HAART) or was on HAART in the 3 months prior to recruitment
Key Trial Info
Start Date :
November 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 29 2021
Estimated Enrollment :
1100 Patients enrolled
Trial Details
Trial ID
NCT01897909
Start Date
November 1 2011
End Date
July 29 2021
Last Update
July 29 2021
Active Locations (1)
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1
Komfo Anokye Teaching Hospital
Kumasi, Ashanti Region, Ghana