Status:
COMPLETED
Optimizing Local Anesthetic Concentration for Continuous Popliteal-Sciatic Nerve Blocks
Lead Sponsor:
University of California, San Diego
Collaborating Sponsors:
Baxter Healthcare Corporation
Conditions:
Relatively Healthy Volunteers
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
A continuous peripheral nerve block-also termed "perineural local anesthetic infusion"-involves the insertion of a tiny tube (a "catheter") through the skin and adjacent to a peripheral nerve, followe...
Detailed Description
The investigators therefore propose a volunteer-based clinical trial testing the hypothesis that providing ropivacaine at different concentrations and rates (0.1% at 8 mL/hour vs. 0.4% at 2 mL/hour)-b...
Eligibility Criteria
Inclusion
- age ≥ 18 years
- willing to have bilateral femoral perineural catheters placed with a subsequent ropivacaine infusion and motor/sensory testing for 6 hours, requiring an overnight stay in the UCSD GCRC/CTRI to allow dissipation of local anesthetic infusion effects by the following morning
Exclusion
- current daily analgesic use
- opioid use within the previous 4 weeks
- any neuro-muscular deficit of either femoral nerves and/or quadriceps muscles
- morbid obesity \[weight \> 35 kg/m2\]
- pregnancy (as determined by a urine pregnancy test prior to any study interventions)
- incarceration
- We expect to recruit a maximum of 30 healthy volunteers; with a target goal of 24 for the analysis. Selection for inclusion will not be based on gender, race, or socioeconomic status. The study population of interest includes men and women of all races and socioeconomic status. There will be no participants from vulnerable populations, such as pregnant women, children, or prisoners.
Key Trial Info
Start Date :
July 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2013
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT01898689
Start Date
July 1 2013
End Date
November 1 2013
Last Update
March 19 2021
Active Locations (1)
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1
University California San Diego
San Diego, California, United States, 92103