Status:
UNKNOWN
Study of the Telomere-telomerase System and the Expression of Candidate Genes in the Leukocytes of Patients With Depressive Disorder: Search for Peripheral Markers of Somatic Stress
Lead Sponsor:
Centre Hospitalier Universitaire Dijon
Conditions:
Depressive Disorder
Eligibility:
All Genders
Phase:
NA
Brief Summary
The mechanisms of oxidative stress and inflammation involved in mood disorders are factors of chronicity and severity. These mechanisms induce a phenomenon of accelerated cellular senescence and are r...
Eligibility Criteria
Inclusion
- Persons who have given their written informed consent
- absence of a diagnosis of major depressive disorder throughout the study and no history of psychiatric disorders
- diagnosis of a first episode of a major depressive disorder
- diagnosis of a recurrent major depressive disorder (at least three episodes) with or without resistance to therapy
- Remarks:
- the diagnosis of major depressive disorder with characteristics of melancholy must be clearly mentioned in the case report form but is not a reason for not being included in the study
- the presence of a recent or older attempted suicide must lead to a careful clinical assessment of the diagnosis of depressive disorder and must be clearly mentioned in the case report form.
Exclusion
- Persons not covered by the national Health Insurance Agency
- Psychotic or bipolar disorders
- Severe personality disorders
- cardiovascular disease, proven inflammatory disease and cancer
- persons unable to give their consent personally,
- persons in emergency situations,
- pregnant women,
- breast-feeding women
Key Trial Info
Start Date :
April 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01903655
Start Date
April 1 2010
Last Update
July 19 2013
Active Locations (1)
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1
CHU de Dijon
Dijon, France, 21079